Los trastornos psiqui\u00e1tricos son altamente heredables y polig\u00e9nicos, influenciados por factores ambientales y a menudo com\u00f3rbidos. Los estudios de asociaci\u00f3n a nivel del genoma (GWAS, por sus siglas en ingl\u00e9s) a gran escala, mediante esfuerzos de consorcios, han identificado loci de riesgo gen\u00e9tico y revelado la biolog\u00eda subyacente de los trastornos y rasgos psiqui\u00e1tricos. Sin embargo, m\u00e1s del 85% de los participantes en los GWAS psiqui\u00e1tricos son de ascendencia europea, lo que limita la aplicabilidad de estos hallazgos a las poblaciones no europeas. Am\u00e9rica Latina y el Caribe, regiones caracterizadas por una mezcla gen\u00e9tica diversa, entornos distintivos y disparidades en la atenci\u00f3n sanitaria, siguen siendo cr\u00edticamente subestudiadas en la gen\u00f3mica psiqui\u00e1trica. Esto pone en peligro el acceso a la psiquiatr\u00eda de precisi\u00f3n, donde la diversidad es crucial para la innovaci\u00f3n y la equidad. Esta revisi\u00f3n eval\u00faa el estado actual y los avances en la gen\u00f3mica psiqui\u00e1trica dentro de Am\u00e9rica Latina y el Caribe, discute la prevalencia y la carga de los trastornos psiqui\u00e1tricos, explora las contribuciones a los GWAS psiqui\u00e1tricos de estas regiones y destaca m\u00e9todos que tienen en cuenta la diversidad gen\u00e9tica. Tambi\u00e9n identificamos las brechas y desaf\u00edos existentes y proponemos recomendaciones para promover la equidad en la gen\u00f3mica psiqui\u00e1trica.<\/p>\n\n\n\n
Psychiatric disorders are highly heritable and polygenic, influenced by environmental factors and often comorbid. Large-scale genome-wide association studies (GWASs) through consortium efforts have identified genetic risk loci and revealed the underlying biology of psychiatric disorders and traits. However, over 85% of psychiatric GWAS participants are of European ancestry, limiting the applicability of these findings to non-European populations. Latin America and the Caribbean, regions marked by diverse genetic admixture, distinct environments and healthcare disparities, remain critically understudied in psychiatric genomics. This threatens access to precision psychiatry, where diversity is crucial for innovation and equity. This Review evaluates the current state and advancements in psychiatric genomics within Latin America and the Caribbean, discusses the prevalence and burden of psychiatric disorders, explores contributions to psychiatric GWASs from these regions and highlights methods that account for genetic diversity. We also identify existing gaps and challenges and propose recommendations to promote equity in psychiatric genomics.<\/p>\n","protected":false},"excerpt":{"rendered":"
Los trastornos psiqui\u00e1tricos son altamente heredables y polig\u00e9nicos, influenciados por factores ambientales y a menudo com\u00f3rbidos. Los estudios de asociaci\u00f3n a nivel del genoma (GWAS, por sus siglas en ingl\u00e9s) a gran escala, mediante esfuerzos de consorcios, han identificado loci de riesgo gen\u00e9tico y revelado la biolog\u00eda subyacente de los trastornos y rasgos psiqui\u00e1tricos. Sin…<\/p>\n","protected":false},"author":1,"featured_media":44528,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-44527","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categoria"],"acf":[],"_links":{"self":[{"href":"https:\/\/familia-digital-monterrey.com\/comenzardenuevo\/wp-json\/wp\/v2\/posts\/44527","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/familia-digital-monterrey.com\/comenzardenuevo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/familia-digital-monterrey.com\/comenzardenuevo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/familia-digital-monterrey.com\/comenzardenuevo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/familia-digital-monterrey.com\/comenzardenuevo\/wp-json\/wp\/v2\/comments?post=44527"}],"version-history":[{"count":1,"href":"https:\/\/familia-digital-monterrey.com\/comenzardenuevo\/wp-json\/wp\/v2\/posts\/44527\/revisions"}],"predecessor-version":[{"id":44529,"href":"https:\/\/familia-digital-monterrey.com\/comenzardenuevo\/wp-json\/wp\/v2\/posts\/44527\/revisions\/44529"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/familia-digital-monterrey.com\/comenzardenuevo\/wp-json\/wp\/v2\/media\/44528"}],"wp:attachment":[{"href":"https:\/\/familia-digital-monterrey.com\/comenzardenuevo\/wp-json\/wp\/v2\/media?parent=44527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/familia-digital-monterrey.com\/comenzardenuevo\/wp-json\/wp\/v2\/categories?post=44527"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/familia-digital-monterrey.com\/comenzardenuevo\/wp-json\/wp\/v2\/tags?post=44527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}